Unlock infinite chemical potential

We’re transforming chemical manufacturing using cascades of enzymes to make any molecule using nature’s catalysts.

Our vision of sustainability

We enable enzymes, nature’s biochemical machinery, to create durable and cost-effective chemical products.

More than just a business solution, our vision combats climate change by shifting from petroleum to enzyme-based manufacturing, aligning economic benefits with environmental preservation and humanity's wellbeing.

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Founding Story

The son of an industrial hygienist and entrepreneur, James spent his summers growing up in a lab, testing building materials for lead and asbestos (as young kids do).

This gave James a glimpse at the negative impacts of the chemical industry, inspiring him to earn a Ph.D. in Chemical and Biological Engineering so he could clean up the industry from the inside.

After a stint as a management consultant at Bain, Alex spent years at Zymergen, one of the largest biomanufacturing companies, looking to use nature’s catalysts to create molecules more sustainably. There, he saw the difficulty and cost of scaling microbial processes and became excited about the promise of enzymes.

While enzyme immobilization goes back over 100 years, success for a given enzyme and application remained a matter of luck. Motivated by a lack of rational and data-driven approaches, James developed new materials to capture and retain enzyme activity under the toughest conditions.

When Alex met James, he knew that James’s innovation needed to be commercialized. After 6 months of getting to know each other, they started Cascade Bio in December 2022.

two men standing next to each other in front of a machine

Meet the team

James Weltz
James Weltz
CO-FOUNDER AND CSO
Inventor of Cascade’s underlying technology to stabilize enzymes. With a decade of biocatalysis experience, he’ll take your enzymes to the next level. In his free time, he enjoys all things outdoors in colorful Colorado.
Alex Rosay
Alex Rosay
CO-FOUNDER AND CEO
Big believer in the enzymatic future. Industry experience from Zymergen and Bain and a ChemE background from Stanford. Avid traveler, beach volleyball player and board gamer based in Brooklyn, New York.
Laura Macdougall
Laura Macdougall
SENIOR SCIENTIST
Laura is a polymer chemist who enjoys discovering how polymers can change the world. She takes Cascade’s underlying tech to the next level. When she is not in the lab Laura loves hiking and cycling around Colorado.
Ryan Cole
Ryan Cole
RESEARCH ASSOCIATE
Ryan brings 5+ years of molecular biology and biochemistry experience to help demonstrate the efficacy and robustness of our enzyme technology. He loves all things exercise and sports and can likely be found at the nearby gym or hockey rink.
Adam Fraites
Adam Fraites
SCIENTIST
Adam is a protein biochemist who brings years of experience in protein expression, purification and characterization. He enjoys examining the underlying structure function relationship of enzymes which he applies to Cascade’s underlying technology. When not in the lab Adam loves hiking and golfing all throughout Colorado.
Abby Barmore
Abby Barmore
LAB ANALYST
Abby recently joins Cascade with a chemical engineering background from CU Boulder. Focused on quality control, she meticulously tests resins and immobilized enzymes to ensure they meet rigorous standards before they are sent to solve problems around the world. As a nature enthusiast, Abby can be found hiking or skiing throughout the Colorado mountains in her free time.
Matt Fate
Matt Fate
Senior Research Associate
Matt is a synthetic chemist dedicated to leveraging biocatalysis to make a global impact. He thrives on tackling complex problems to enhance Cascade’s technology. Outside of work, Matt enjoys exploring the Colorado mountains and playing soccer.
John Warner
John Warner
SCIENTIFIC ADVISOR
One of the founders of the field of Green Chemistry. With 330+ patents and 9 ongoing companies based on his inventions, he spends his time designing new molecules and materials while playing music and adventuring with his family outdoors and in Azeroth.
Dipnath Baidyaroy
Dipnath Baidyaroy
BUSINESS ADVISOR
Dipnath has >20 years of techno-commercial experience in biotechnology. He currently serves as Vice President and Head of Business at Inscripta. Before that, he was head of Alliance & Products Management at Codexis. His PhD is in Microbiology.
Tim Hitchman
Tim Hitchman
BUSINESS ADVISOR
Tim has broad experience in bio-based products, with senior leadership roles in product development and operations. Living in Carlsbad, CA with his fiancé, son and two dogs, in his spare time he can be found out on local and far flung trails biking or hiking.

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Let’s build something together.